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A 3 year old child had a severe viral illness, a few days later there were repeated vomiting, loss of consciousness and convulsions. Laboratory blood tests revealed hyperammonemia.

what is it hyperammonemia? when there is hyperammonemia? Inc^ NH3 in blood Metabolic fate of ammonia. Formation of urea, amination of ketoacid, Glutamate to glutamine, ketogluterate to glutamate Transport of ammonia. NH3+Glutamate -> glutamine  -> glutamate +NH3--->urea cycle (tissue blood liver) Reactions of urea cycle. Significance of urea cycle. Dec^ NH3 and make it safe for excretion Regulation of urea cycle . Carbonyl phosphate syanthesis-> rate controling enzyme Metabolic inborn errors of urea cycle 6 enzymes of the cycle CPS1, NAGS, OTC, AS, ASL, AG
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A 42-year-old man suffers from rheumatoid arthritis. Aspirin, as inhibitor of prostaglandin synthesis, is included in the complex of drugs prescribed to him.

Aspirin. Properties, Mechanism of action, also acetyl salicylic acid, it is NSAID (non-steroidal)C9H8O4 .....Action blocks prostaglandins synthesis What are eicosanoids? signaling molecule made by oxidation of Aracidunic Acid Types of eicosanoids. Prostaglandins, Prostacyclins, Thromboxyn, Leukotriene Function of prostaglandins. Conriction and dilation of smooth muscles(pain singniling) inc^ CAMP in Endocrine gland......Dec^ CAMP in adipose tissue, gastric secretion , insulin secretion, Synthesis of prostaglandins. Substrates . DiAcylGlycerol, phosphoglycerol
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how many chiral centers are in the molecule of promedol

2
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Alanine is an amino acid with a non polar radical, is essential

1 L-isomeres 2-aminopropanoic acid
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glucose is an optically active substance, formed during the hydrolysis of starch

4 16 polarimetry
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Myocardial infarction, injuries and surgical interventions may be accompanied by thrombosis.

Blood coagulation system in book Mechanism of fibrinolysis. - plasmine urokinase Blood coagulation disorders von Willebrand disease ,hemophilia a-8, b-9,c-11 The role of the vascular wall in the coagulation system? synthesis of thromboxane and endothileum . What kind vitamins are necessary for normal functioning of the coagulation system? vit k Anticoagulants. Representatives. Characteristics. direct ans indirect..heparin an warfarin
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A young girl turned to a dermatologist about redness, swelling and itching that appeared on open skin areas after a country walk on a sunny day. The patient took sulfonamides due to the exacerbation of chronic bronchitis. 5-aminolevulinate and porphobilinogen were detected in the patient's blood, urine was colored red.

What is the preliminary diagnosis  porphyrias(hepatic) Metabolic disturbance of which substance is observed in this case  heme Why urine has red color in this case  due to porphyrins Heme synthesis. Reactions. Regulation  ALAS What heme synthesis enzyme is induced by sulfonamides  aminoleulanate synthase
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