A 42-year-old man suffers from rheumatoid arthritis. Aspirin, as inhibitor of prostaglandin synthesis, is included in the complex of drugs prescribed to him.


Aspirin. Properties, Mechanism of action,also acetyl salicylic acid, it is NSAID (non-steroidal)C9H8O4 .....Action blocks prostaglandins synthesis

What are eicosanoids?signaling molecule made by oxidation of Aracidunic Acid

Types of eicosanoids. Prostaglandins, Prostacyclins, Thromboxyn, Leukotriene

Function of prostaglandins. Conriction and dilation of smooth muscles(pain singniling)
inc^ CAMP in Endocrine gland......Dec^ CAMP in adipose tissue, gastric secretion , insulin secretion,

Synthesis of prostaglandins. Substrates. DiAcylGlycerol, phosphoglycerol

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