A 48-year-old patient went to the doctor with complaints of severe pain, swelling, reddening of the joints, fever (up to 38 °C). High content of urates was revealed in the blood.


Justify the preliminary diagnosis. What is the cause of the diseaseGOUT, due to high uric acid in blood
metabolism some substances are brokenBreakdown of purines , salvage pathway of purine metabolism
Why in the blood has a high content of uratedue to high uric acid
Laboratory diagnosis of this conditionUric acid in blood

Comments

Post a Comment

Popular posts from this blog

A 3 year old child had a severe viral illness, a few days later there were repeated vomiting, loss of consciousness and convulsions. Laboratory blood tests revealed hyperammonemia.

what is it hyperammonemia? when there is hyperammonemia? Inc^ NH3 in blood Metabolic fate of ammonia. Formation of urea, amination of ketoacid, Glutamate to glutamine, ketogluterate to glutamate Transport of ammonia. NH3+Glutamate -> glutamine  -> glutamate +NH3--->urea cycle (tissue blood liver) Reactions of urea cycle. Significance of urea cycle. Dec^ NH3 and make it safe for excretion Regulation of urea cycle . Carbonyl phosphate syanthesis-> rate controling enzyme Metabolic inborn errors of urea cycle 6 enzymes of the cycle CPS1, NAGS, OTC, AS, ASL, AG
Read more